Hepatic Dose : No dose adjustment recommended. Patients should avoid foods that contain vitamin K while taking the medication. Dose as in normal renal functionĭialysed. Vitamin K, a fat-soluble vitamin that the body stores in limited quantities, is the antidote for Coumadin® overdose it also contributes to vascular and bone health. Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death. Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Pain, swelling, and tenderness at the injection site may occur. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur. Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. Alternatively, 10 mg IV, IM or subcutaneously may be administered. The vitamin K- dependent coagulation factors II, VII, IX, and X require -carboxylation for their procoagulant activ- ity, and treatment with VKAs results in.
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